Action
- Obtain history, physical examination, vital signs, pulse oximetry reading, respiratory status, hydration status, and ability to maintain hydration
- Disease severity is assessed based on history and physical examination. Severe disease (as defined in the 2014 American Academy of Pediatrics guidelines): signs and symptoms associated with poor feeding; respiratory distress characterized by tachypnea, nasal flaring, and hypoxemia.
- Assess risk for severe bronchiolitis and apnea (See Table 2)
- Assess the patient frequently (due to variable disease course)
- Consider nasal suction prior to repeated examinations
Decision
Is there improvement in respiratory status after suctioning?
Background
Nasal Suction
Nasal suction should be used to clear secretions in infants with acute bronchiolitis if they exhibit respiratory distress or difficulties in feeding or sleeping. This is especially important in younger infants, who are obligatory nose breathers. One study reported that nasal aspiration decreased hospital length of stay; however, routine use of nasopharyngeal suctioning was associated with longer length of stay for patients admitted with bronchiolitis. This same study reported longer length of stays for hospitalized patients when >4 hour lapse in time occurred between suctioning. This seemingly conflicting data is likely due to the retrospective nature of the study. Because of the limited studies available, the 2014 AAP guidelines did not make a recommendation for or against the use of suctioning.
A small prospective study comparing nasal aspiration to nasopharyngeal suctioning demonstrated that nasopharyngeal suctioning resulted in more mucus removal than nasal aspiration. Nasopharyngeal suctioning had improved lung impedance 30 minutes post suctioning, which was not seen with nasal aspiration. This suggests that nasopharyngeal suctioning may be beneficial in some patients.
Evidence-based medicine requires a critical appraisal of the literature based upon study methodology and number of subjects. Not all references are equally robust. The findings of a large, prospective, randomized, and blinded trial should carry more weight than a case report.
To help the reader judge the strength of each reference, pertinent information about the study is included in bold type following the reference, where available. In addition, the most informative references cited in this paper, as determined by the authors, are noted by an asterisk (*) next to the number of the reference.
- McLaurin KK, Farr AM, Wade SW, et al. Respiratory syncytial virus hospitalization outcomes and costs of full-term and preterm infants. J Perinatol. 2016;36(11):990-996. (Retrospective multicenter study; 4 million newborns)
- Hasegawa K, Tsugawa Y, Brown DF, et al. Trends in bronchiolitis hospitalizations in the United States, 2000-2009. Pediatrics. 2013;132(1):28-36. (Nationwide serial cross-sectional analysis; 544,828 patients aged <2 years)
- Ralston SL, Lieberthal AS, Meissner HC, et al. Clinical practice guideline: the diagnosis, management, and prevention of bronchiolitis. Pediatrics. 2014;134(5):e1474-e1502. (Clinical practice guideline) DOI: 10.1542/peds.2014-2742
- Mansbach JM, Espinola JA, Macias CG, et al. Variability in the diagnostic labeling of nonbacterial lower respiratory tract infections: a multicenter study of children who presented to the emergency department. Pediatrics. 2009;123(4):e573-e581. (Retrospective study; 928 patients aged <2 years) DOI: 10.1542/peds.2008-1675
- Jartti T, Lehtinen P, Vuorinen T, et al. Bronchiolitis: age and previous wheezing episodes are linked to viral etiology and atopic characteristics. Pediatr Infect Dis J. 2009;28(4):311-317. (Prospective study; 259 patients aged 0-36 months)
- Jartti T, Mäkelä MJ, Vanto T, et al. The link between bronchiolitis and asthma. Infect Dis Clin North Am. 2005;19(3):667-689. (Review)
- Swingler GH, Hussey GD, Zwarenstein M. Duration of illness in ambulatory children diagnosed with bronchiolitis. Arch Pediatr Adolesc Med. 2000;154(10):997-1000. (Prospective study; 181 patients aged 2-23 months)
- Wright AL, Taussig LM, Ray CG, et al. The Tucson Children's Respiratory Study II. Lower respiratory tract illness in the first year of life. Am J Epidemiol. 1989;129(6):1232-1246. (Prospective study; 1246 patients aged <1 year)
- Rakes GP, Arruda E, Ingram JM, et al. Rhinovirus and respiratory syncytial virus in wheezing children requiring emergency care IgE and eosinophil analyses. Am J Respir Crit Care Med. 1999;159(3):785-790. (Case-control study; 129 patients aged 2 months-16 years)
- Kahn JS. Epidemiology of human metapneumovirus. Clin Microbiol Rev. 2006;19(3):546-557. (Epidemiologic report)
- van den Hoogen BG, de Jong JC, Groen J, et al. A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat Med. 2001;7(6):719-724. (Prospective study; 28 patients)
- Wolf DG, Greenberg D, Kalkstein D, et al. Comparison of human metapneumovirus, respiratory syncytial virus and influenza A virus lower respiratory tract infections in hospitalized young children. Pediatr Infect Dis J. 2006;25(4):320-324. (Prospective study; 516 patients)
- Williams JV, Tollefson SJ, Heymann PW, et al. Human metapneumovirus infection in children hospitalized for wheezing. J Allergy Clin Immunol. 2005;115(6):1311-1312. (Editorial)
- Williams JV, Harris PA, Tollefson SJ, et al. Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children. N Engl J Med. 2004;350(5):443-450. (Prospective study; 463 patients)
- Miller EK, Lu X, Erdman DD, et al. Rhinovirus-associated hospitalizations in young children. J Infect Dis. 2007;195(6):773-781. (Population-based surveillance study; 156 patients aged <5 years)
- Peltola V, Waris M, Osterback R, et al. Clinical effects of rhinovirus infections. J Clin Virol. 2008;43(4):411-414. (Review)
- Jartti T, Lehtinen P, Vuorinen T, et al. Respiratory picornaviruses and respiratory syncytial virus as causative agents of acute expiratory wheezing in children. Emerg Infect Dis. 2004;10(6):1095-1101. (Population-based surveillance study; 293 patients aged <2 years)
- Semple MG, Cowell A, Dove W, et al. Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis. J Infect Dis. 2005;191(3):382-386. (Population-based surveillance; 196 patients aged <2 years)
- Brand HK, de Groot R, Galama JM, et al. Infection with multiple viruses Is not associated with increased disease severity in children with bronchiolitis. Pediatr Pulmonol. 2012;47(4):393-400. (Prospective study; 142 children aged <2 years)
- Heitlinger LA. Guideline for management of pediatric gastroesophageal reflux. JAMA Otolaryngol Head Neck Surg. 2018;144(8):755-756. (Clinical guidelines)
- Castro-Rodríguez JA, Holberg CJ, Wright AL, et al. A clinical index to define risk of asthma in young children with recurrent wheezing. Am J Respir Crit Care Med. 2000;162(4 Pt 1):1403-1406. (Longitudinal study; 1246 newborns)
- Koponen P, Helminen M, Paassilta M, et al. Preschool asthma after bronchiolitis in infancy. Eur Respir J. 2012;39(1):76-80. (Prospective study; 205 infants <6 months of age)
- United States Centers for Disease Control and Prevention. Interim infection prevention and control recommendations for healthcare personnel during the coronavirus disease 2019 (COVID-19) pandemic. Accessed December 10, 2022. (CDC interim guidance)
- American Academy of Pediatrics. Use of personal protective equipment (PPE) for pediatric care in ambulatory care settings during the SARS-CoV-2 pandemic. Updated December 8, 2022. Accessed December 10, 2022. (Interim clinical guidance)
- Wang EE, Law BJ, Stephens D. Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC) prospective study of risk factors and outcomes in patients hospitalized with respiratory syncytial viral lower respiratory tract infection. J Pediatr. 1995;126(2):212-219. (Prospective population-based study; 689 patients aged <2 years)
- Shaw KN, Bell LM, Sherman NH. Outpatient assessment of infants with bronchiolitis. Am J Dis Child. 1991;145(2):151-155. (Prospective population-based study; 230 patients aged <13 months)
- Chan PW, Lok FY, Khatijah SB. Risk factors for hypoxemia and respiratory failure in respiratory syncytial virus bronchiolitis. Southeast Asian J Trop Med Public Health. 2002;33(4):806-810. (Prospective population-based study; 216 children aged <24 months)
- MacDonald NE, Hall CB, Suffin SC, et al. Respiratory syncytial viral infection in infants with congenital heart disease. N Engl J Med. 1982;307(7):397-400. (Prospective population-based study; 699 children aged <12 months)
- Hall CB, Powell KR, MacDonald NE, et al. Respiratory syncytial viral infection in children with compromised immune function. N Engl J Med. 1986;315(2):77-81. (Prospective population-based study; 608 children aged <5 years)
- Freire G, Kuppermann N, Zemek R, et al. Predicting escalated care in infants with bronchiolitis. Pediatrics. 2018;142(3). (Retrospective cohort study; 2722 patients)
- Hall CB, Kopelman AE, Douglas RG, Jr., et al. Neonatal respiratory syncytial virus infection. N Engl J Med. 1979;300(8):393-396. (Prospective population-based study; 82 neonates)
- Anas N, Boettrich C, Hall CB, et al. The association of apnea and respiratory syncytial virus infection in infants. J Pediatr. 1982;101(1):65-68. (Prospective study; 32 patients aged <18 months)
- Kneyber MC, Brandenburg AH, de Groot R, et al. Risk factors for respiratory syncytial virus associated apnoea. Eur J Pediatr. 1998;157(4):331-335. (Retrospective review; 185 patients aged <12 months)
- Church NR, Anas NG, Hall CB, et al. Respiratory syncytial virus-related apnea in infants. Demographics and outcome. Am J Dis Child. 1984;138(3):247-250. (Retrospective review; 261 patients aged <12 months)
- Willwerth BM, Harper MB, Greenes DS. Identifying hospitalized infants who have bronchiolitis and are at high risk for apnea. Ann Emerg Med. 2006;48(4):441-447. (Retrospective review; 691 patients aged <6 months) DOI: 10.1016/j.annemergmed.2006.03.021
- Schroeder AR, Mansbach JM, Stevenson M, et al. Apnea in children hospitalized with bronchiolitis. Pediatrics. 2013;132(5):e1194-e1201. (Review)
- Roback MG, Baskin MN. Failure of oxygen saturation and clinical assessment to predict which patients with bronchiolitis discharged from the emergency department will return requiring admission. Pediatr Emerg Care. 1997;13(1):9-11. (Retrospective case-control study; 57 patients aged <1 year)
- Ashton R, Connolly K. The relation of respiration rate and heart rate to sleep states in the human newborn. Dev Med Child Neurol. 1971;13(2):180-187. (Observational study; 22 newborns)
- Iliff A, Lee VA. Pulse rate, respiratory rate, and body temperature of children between two months and eighteen years of age. Child Dev. 1952;23(4):237-245. (Prospective study; 197 patients)
- Berman S, Simoes EA, Lanata C. Respiratory rate and pneumonia in infancy. Arch Dis Child. 1991;66(1):81-84. (Review article)
- Mahabee-Gittens EM, Grupp-Phelan J, Brody AS, et al. Identifying children with pneumonia in the emergency department. Clin Pediatr (Phila). 2005;44(5):427-435. (Prospective cohort study; 510 patients aged 2-59 months)
- Lowell DI, Lister G, Von Koss H, et al. Wheezing in infants: the response to epinephrine. Pediatrics. 1987;79(6):939-945. (Double-blind randomized trial; 42 patients aged <24 months)
- Viswanathan M, King VJ, Bordley C, et al. Management of bronchiolitis in infants and children: summary. 2003. In: AHRQ Evidence Report Summaries. Agency for Healthcare Research and Quality (US); 1998-2005. (Evidence report)
- Mansbach JM, Clark S, Christopher NC, et al. Prospective multicenter study of bronchiolitis: predicting safe discharges from the emergency department. Pediatrics. 2008;121(4):680-688. (Prospective multicenter study; 1456 patients aged <2 years) DOI: 10.1542/peds.2007-1418
- Mallory MD, Shay DK, Garrett J, et al. Bronchiolitis management preferences and the influence of pulse oximetryand respiratory rate on the decision to admit. Pediatrics. 2003;111(1):e45-e51. (Cross-sectional study) DOI: 10.1542/peds.111.1.e45
- Ross PA, Newth CJ, Khemani RG. Accuracy of pulse oximetry in children. Pediatrics. 2014;133(1):22-29. (Prospective multicenter observational study; 255 patients aged <18 years) DOI: 10.1542/peds.2013-1760
- Dawson KP, Long A, Kennedy J, et al. The chest radiograph in acute bronchiolitis. J Paediatr Child Health. 1990;26(4):209-211. (Review)
- Roosevelt G, Sheehan K, Grupp-Phelan J, et al. Dexamethasone in bronchiolitis: a randomised controlled trial. Lancet. 1996;348(9023):292-295. (Randomized double-blind prospective; 197 patients aged <12 months)
- Swingler GH, Hussey GD, Zwarenstein M. Randomised controlled trial of clinical outcome after chest radiograph in ambulatory acute lower-respiratory infection in children. Lancet. 1998;351(9100):404-408. (Randomized controlled trial; 522 children aged 2-59 months)
- Schuh S, Lalani A, Allen U, et al. Evaluation of the utility of radiography in acute bronchiolitis. J Pediatr. 2007;150(4):429-433. (Prospective cohort study; 265 infants aged 2-23 months)
- Henrickson KJ, Hall CB. Diagnostic assays for respiratory syncytial virus disease. Pediatr Infect Dis J. 2007;26(11 Suppl):S36-S40. (Review)
- American College of Emergency Physicians Clinical Policies Subcommittee (Writing Committee) on Pediatric Fever, Mace SE, Gemme SR, et al. Clinical policy for well-appearing infants and children younger than 2 years of age presenting to the emergency department with fever. Ann Emerg Med. 2016;67(5):625-639. (Clinical guideline)
- Levine DA, Platt SL, Dayan PS, et al. Risk of serious bacterial infection in young febrile infants with respiratory syncytial virus infections. Pediatrics. 2004;113(6):1728-1734. (Multicenter prospective cross-sectional study; 1248 patients aged 60 days) DOI: 10.1542/peds.113.6.1728
- Purcell K, Fergie J. Concurrent serious bacterial infections in 2396 infants and children hospitalized with respiratory syncytial virus lower respiratory tract infections. Arch Pediatr Adolesc Med. 2002;156(4):322-324. (Retrospective review; 2396 patients aged <12 months)
- McDaniel CE, Ralston S, Lucas B, et al. Association of diagnostic criteria with urinary tract infection prevalence in bronchiolitis: a systematic review and meta-analysis. JAMA Pediatr. 2019;173(3):269-277. (Systematic review and meta-analysis)
- Schuh S, Babl FE, Dalziel SR, et al. Practice variation in acute bronchiolitis: a Pediatric Emergency Research Networks Study Pediatrics. 2017;140(6). (Retrospective cohort study; 3725 patients aged <12 months)
- House SA, Marin JR, Hall M, et al. Trends over time in use of nonrecommended tests and treatments since publication of the American Academy of Pediatrics Bronchiolitis Guideline. JAMA Netw Open. 2021;4(2):e2037356. (Retrospective cohort; 602,375 encounters) DOI: 10.1001/jamanetworkopen.2020.37356
- Shay DK, Holman RC, Newman RD, et al. Bronchiolitis-associated hospitalizations among US children, 1980-1996. JAMA. 1999;282(15):1440-1446. (Review)
- O'Brien LM, Stebbens VA, Poets CF, et al. Oxygen saturation during the first 24 hours of life. Arch Dis Child Fetal Neonatal Ed. 2000;83(1):F35-F38. (Prospective study; 90 patients)
- Hunt CE, Corwin MJ, Lister G, et al. Longitudinal assessment of hemoglobin oxygen saturation in healthy infants during the first 6 months of age. Collaborative Home Infant Monitoring Evaluation (CHIME) Study Group. J Pediatr. 1999;135(5):580-586. (Prospective study; 64 patients)
- Horn SD, Smout RJ. Effect of prematurity on respiratory syncytial virus hospital resource use and outcomes. J Pediatr. 2003;143(5 Suppl):S133-S141. (Retrospective review; 304 patients)
- Rojas-Reyes MX, Granados Rugeles C, Charry-Anzola LP. Oxygen therapy for lower respiratory tract infections in children between 3 months and 15 years of age. Cochrane Database Syst Rev. 2014;(12):CD005975. (Systematic review; 4 studies, 479 patients)
- Schuh S, Freedman S, Coates A, et al. Effect of oximetry on hospitalization in bronchiolitis: a randomized clinical trial. JAMA. 2014;312(7):712-718. (Multicenter randomized clinical trial; 229 infants) DOI: 10.1001/jama.2014.8637
- Principi T, Coates AL, Parkin PC, et al. Effect of oxygen desaturations on subsequent medical visits in infants discharged from the emergency department with bronchiolitis. JAMA Pediatr. 2016;170(6):602-608. (Prospective cohort study; 118 patients) DOI: 10.1001/jamapediatrics.2016.0114
- Quinonez RA, Garber MD, Schroeder AR, et al. Choosing wisely in pediatric hospital medicine: five opportunities for improved healthcare value. J Hosp Med. 2013;8(9):479-485. (Recommendations)
- Schondelmeyer AC, Dewan ML, Brady PW, et al. Cardiorespiratory and pulse oximetry monitoring in hospitalized children: a delphi process. Pediatrics. 2020;146(2):e20193336. (Review of recommendations) DOI: 10.1542/peds.2019-3336
- Khoshoo V, Edell D. Previously healthy infants may have increased risk of aspiration during respiratory syncytial viral bronchiolitis. Pediatrics. 1999;104(6):1389-1390. (Prospective study; 12 patients)
- Babl FE, Franklin D, Schlapbach LJ, et al. Enteral hydration in high-flow therapy for infants with bronchiolitis: Secondary analysis of a randomised trial. J Paediatr Child Health. 2020;56(6):950-955. (Secondary analysis of multicenter randomized controlled trial; 505 patients)
- Sochet AA, Nunez M, Wilsey MJ, et al. Enteral nutrition improves vital signs in children with bronchiolitis on noninvasive ventilation. Hosp Pediatr. 2021;11(2):135-143. (Retrospective cohort study; 124 patients)
- Slain KN, Martinez-Schlurmann N, Shein SL, et al. Nutrition and high-flow nasal cannula respiratory support in children with bronchiolitis. Hosp Pediatr. 2017;7(5):256-262. (Retrospective; 70 patients)
- Sochet AA, McGee JA, October TW. Oral nutrition in children with bronchiolitis on high-flow nasal cannula is well tolerated. Hosp Pediatr. 2017;7(5):249-255. (Prospective, observational cohort; 132 patients)
- Wang J, Xu E, Xiao Y. Isotonic versus hypotonic maintenance IV fluids in hospitalized children: a meta-analysis. Pediatrics. 2014;133(1):105-113. (Meta-analysis; 10 randomized controlled trials)
- Scottish Intercollegiate Guidelines Network. Guideline No. 91: Bronchiolitis in Children. NHS Quality Improvement Scotland; 2006. (Clinical guidelines [withdrawn in 2016])
- Working Group of the Clinical Practice Guideline on Acute Bronchiolitis. Clinical Practice Guideline on Acute Bronchiolitis; Quality Plan for the Spanish National Healthcare System of the Spanish Ministry for Health and Social Policy. Catalan Agency for Health Technology Assessment; 2010. (Clinical guidelines)
- Friedman JN, Rieder MJ, Walton JM, et al. Bronchiolitis: recommendations for diagnosis, monitoring and management of children one to 24 months of age. Paediatr Child Health. 2014;19(9):485-498. (Clinical guidelines)
- National Collaborating Centre for Women's and Children's Health (UK). Bronchiolitis: Diagnosis and Management of Bronchiolitis in Children. Published June 1, 2015. Updated August 9, 2021. Accessed December 10, 2022. (Clinical guidelines)
- O'Brien S, Borland ML, Cotterell E, et al. Australasian bronchiolitis guideline. J Paediatr Child Health. 2019;55(1):42-53. (Clinical guidelines)
- Mussman GM, Parker MW, Statile A, et al. Suctioning and length of stay in infants hospitalized with bronchiolitis. JAMA Pediatr. 2013;167(5):414-421. (Retrospective cohort study; 740 infants)
- Ringer CN, Engberg RJ, Carlin KE, et al. Physiologic effects of nasal aspiration and nasopharyngeal suctioning on infants with viral bronchiolitis. Respir Care. 2020;65(7):984-993. (Clinical effectiveness study; 16 patients)
- Gadomski AM, Bhasale AL. Bronchodilators for bronchiolitis. Cochrane Database Syst Rev. 2006;(3):CD001266. (Systematic review; 30 trials, 1992 infants with bronchiolitis) DOI: 10.1002/14651858.CD001266.pub2
- Chavasse R, Seddon P, Bara A, et al. Short acting beta agonists for recurrent wheeze in children under 2 years of age. Cochrane Database Syst Rev. 2002;(3):CD002873. (Meta-analysis; 8 studies)
- Patel H, Platt R, Lozano JM, et al. Glucocorticoids for acute viral bronchiolitis in infants and young children. Cochrane Database Syst Rev. 2004;(3):CD004878. (Systematic review; 13 trials)
- Hartling L, Wiebe N, Russell K, et al. Epinephrine for bronchiolitis. Cochrane Database Syst Rev. 2004;(1):CD003123. (Systematic review; 14 studies)
- Christakis DA, Cowan CA, Garrison MM, et al. Variation in inpatient diagnostic testing and management of bronchiolitis. Pediatrics. 2005;115(4):878-884. (Systematic review; 17,397 patients aged <12 months)
- Willson DF, Horn SD, Hendley JO, et al. Effect of practice variation on resource utilization in infants hospitalized for viral lower respiratory illness. Pediatrics. 2001;108(4):851-855. (Retrospective review; 601 patients aged <12 months)
- Behrendt CE, Decker MD, Burch DJ, et al. International variation in the management of infants hospitalized with respiratory syncytial virus. International RSV Study Group. Eur J Pediatr. 1998;157(3):215-220. (Retrospective review; 1563 patients aged <12 months)
- van Woensel JB, Wolfs TF, van Aalderen WM, et al. Randomised double blind placebo controlled trial of prednisolone in children admitted to hospital with respiratory syncytial virus bronchiolitis. Thorax. 1997;52(7):634-637. (Randomized double-blind placebo-controlled trial; 54 patients aged <2 years)
- Goebel J, Estrada B, Quinonez J, et al. Prednisolone plus albuterol versus albuterol alone in mild to moderate bronchiolitis. Clin Pediatr (Phila). 2000;39(4):213-220. (Randomized placebo controlled trial; 51 patients aged <12 months)
- Csonka P, Kaila M, Laippala P, et al. Oral prednisolone in the acute management of children age 6 to 35 months with viral respiratory infection-induced lower airway disease: a randomized, placebo-controlled trial. J Pediatr. 2003;143(6):725-730. (Randomized placebo-controlled trial; 123 patients aged 6-35 months)
- Kuyucu S, Unal S, Kuyucu N, et al. Additive effects of dexamethasone in nebulized salbutamol or L-epinephrine treated infants with acute bronchiolitis. Pediatr Int. 2004;46(5):539-544. (Randomized controlled trial; 69 patients aged 2-21 months)
- Schuh S, Coates AL, Binnie R, et al. Efficacy of oral dexamethasone in outpatients with acute bronchiolitis. J Pediatr. 2002;140(1):27-32. (Double-blind randomized placebo-controlled trial; 70 patients aged 2-24 months) DOI: 10.1067/mpd.2002.120271
- Corneli HM, Zorc JJ, Mahajan P, et al. A multicenter, randomized, controlled trial of dexamethasone for bronchiolitis. N Engl J Med. 2007;357(4):331-339. (Double-blind randomized trial; 600 patients aged 2-12 months) DOI: 10.1056/NEJMoa071255
- de Blic J. [Use of corticoids in acute bronchiolitis in infants]. Arch Pediatr. 2001;8 Suppl 1:49s-54s. (Review)
- Chao LC, Lin YZ, Wu WF, et al. Efficacy of nebulized budesonide in hospitalized infants and children younger than 24 months with bronchiolitis. Acta Paediatr Taiwan. 2003;44(6):332-335. (Randomized controlled trial; 73 patients aged <2 years)
- Plint AC, Johnson DW, Patel H, et al. Epinephrine and dexamethasone in children with bronchiolitis. N Engl J Med. 2009;360(20):2079-2089. (Multicenter double-blind placebo-controlled trial; 800 infants aged 6 weeks-12 months)
- Fernandes RM, Bialy LM, Vandermeer B, et al. Glucocorticoids for acute viral bronchiolitis in infants and young children. Cochrane Database Syst Rev. 2013;(6):CD004878. (Systematic review; 17 trials)
- Barnes PJ. Scientific rationale for using a single inhaler for asthma control. Eur Respir J. 2007;29(3):587-595. (Review)
- Everard ML, Bara A, Kurian M, et al. Anticholinergic drugs for wheeze in children under the age of two years. Cochrane Database Syst Rev. 2005;(3):CD001279. (Systematic review; 6 trials, 321 infants)
- Goh A, Chay OM, Foo AL, et al. Efficacy of bronchodilators in the treatment of bronchiolitis. Singapore Med J. 1997;38(8):326-328. (Randomized control study; 120 patients aged <24 months)
- Chowdhury D, al Howasi M, Khalil M, et al. The role of bronchodilators in the management of bronchiolitis: a clinical trial. Ann Trop Paediatr. 1995;15(1):77-84. (Randomized clinical trial; 89 patients aged <12 months)
- Wang EE, Milner R, Allen U, et al. Bronchodilators for treatment of mild bronchiolitis: a factorial randomised trial. Arch Dis Child. 1992;67(3):289-293. (Randomized double-blind trial; 62 patients aged <2 years)
- Bye PT, Elkins MR. Other mucoactive agents for cystic fibrosis. Paediatr Respir Rev. 2007;8(1):30-39. (Review)
- Grewal S, Ali S, McConnell DW, et al. A randomized trial of nebulized 3% hypertonic saline with epinephrine in the treatment of acute bronchiolitis in the emergency department. Arch Pediatr Adolesc Med. 2009;163(11):1007-1012. (Randomized double-blind controlled trial; 46 patients aged <12 months)
- Zhang L, Mendoza-Sassi RA, Wainwright C, et al. Nebulised hypertonic saline solution for acute bronchiolitis in infants. Cochrane Database Syst Rev. 2013;(7):CD006458. (Systematic review; 11 trials, 1090 infants)
- Angoulvant F, Bellêttre X, Milcent K, et al. Effect of nebulized hypertonic saline treatment in emergency departments on the hospitalization rate for acute bronchiolitis: A randomized clinical trial. JAMA Pediatr. 2017;171(8):e171333. (Randomized controlled trial; 777 patients)
- Amirav I, Luder AS, Kruger N, et al. A double-blind, placebo-controlled, randomized trial of montelukast for acute bronchiolitis. Pediatrics. 2008;122(6):e1249-1255. (Double-blinded placebo-controlled randomized trial; 70 patients aged <24 months)
- Bisgaard H, Flores-Nunez A, Goh A, et al. Study of montelukast for the treatment of respiratory symptoms of post-respiratory syncytial virus bronchiolitis in children. Am J Respir Crit Care Med. 2008;178(8):854-860. (Randomized double-blind study; 979 patients aged 3-24)
- Bisgaard H. A randomized trial of montelukast in respiratory syncytial virus postbronchiolitis. Am J Respir Crit Care Med. 2003;167(3):379-383. (Randomized double-blind trial; 130 patients aged <3-36 months)
- Mansbach JM, Camargo CA, Jr. Bronchiolitis: lingering questions about its definition and the potential role of vitamin D. Pediatrics. 2008;122(1):177-179. (Review)
- Lee JM, Smith JR, Philipp BL, et al. Vitamin D deficiency in a healthy group of mothers and newborn infants. Clin Pediatr (Phila). 2007;46(1):42-44. (Cross-sectional; 80 patients)
- Ziegler EE, Hollis BW, Nelson SE, et al. Vitamin D deficiency in breastfed infants in Iowa. Pediatrics. 2006;118(2):603-610. (Population-based study; 84 patients aged <12 months)
- Muhe L, Lulseged S, Mason KE, et al. Case-control study of the role of nutritional rickets in the risk of developing pneumonia in Ethiopian children. Lancet. 1997;349(9068):1801-1804. (Case-control study; 500 patients aged <5 years)
- Najada AS, Habashneh MS, Khader M. The frequency of nutritional rickets among hospitalized infants and its relation to respiratory diseases. J Trop Pediatr. 2004;50(6):364-368. (Case-control study; 443 patients aged <2 years)
- Wayse V, Yousafzai A, Mogale K, et al. Association of subclinical vitamin D deficiency with severe acute lower respiratory infection in Indian children under 5 y. Eur J Clin Nutr. 2004;58(4):563-567. (Population-based study; 69 patients aged 2-60 months)
- Wang TT, Nestel FP, Bourdeau V, et al. Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression. J Immunol. 2004;173(5):2909-2912. (Research article)
- Camargo CA, Jr., Ingham T, Wickens K, et al. Cord-blood 25-hydroxyvitamin D levels and risk of respiratory infection, wheezing, and asthma. Pediatrics. 2011;127(1):e180-187. (Population-based study; 922 newborn patients)
- Devereux G, Litonjua AA, Turner SW, et al. Maternal vitamin D intake during pregnancy and early childhood wheezing. Am J Clin Nutr. 2007;85(3):853-859. (Population-based study; 1212 patients aged <5 years)
- Beigelman A, Castro M, Schweiger TL, et al. Vitamin D levels are unrelated to the severity of respiratory syncytial virus bronchiolitis among hospitalized infants. J Pediatric Infect Dis Soc. 2015;4(3):182-188. (Prospective cohort study; 145 patients aged <1 year)
- Kotaniemi-Syrjänen A, Vainionpää R, Reijonen TM, et al. Rhinovirus-induced wheezing in infancy--the first sign of childhood asthma? J Allergy Clin Immunol. 2003;111(1):66-71. (Prospective study; 82 patients)
- Jartti T, Lehtinen P, Vanto T, et al. Evaluation of the efficacy of prednisolone in early wheezing induced by rhinovirus or respiratory syncytial virus. Pediatr Infect Dis J. 2006;25(6):482-488. (Randomized controlled trial; 78 patients aged <2 years)
- Lehtinen P, Ruohola A, Vanto T, et al. Prednisolone reduces recurrent wheezing after a first wheezing episode associated with rhinovirus infection or eczema. J Allergy Clin Immunol. 2007;119(3):570-575. (Randomized controlled trial; 118 patients aged <2 years)
- Beigelman A, Bacharier LB. Early-life respiratory infections and asthma development: role in disease pathogenesis and potential targets for disease prevention. Curr Opin Allergy Clin Immunol. 2016;16(2):172-178. (Review)
- Johnson DW, Adair C, Brant R, et al. Differences in admission rates of children with bronchiolitis by pediatric and general emergency departments. Pediatrics. 2002;110(4):e49. (Retrospective cohort review; 3091 patients)
- Luo G, Johnson MD, Nkoy FL, et al. Appropriateness of hospital admission for emergency department patients with bronchiolitis: secondary analysis. JMIR Med Inform. 2018;6(4):e10498. (Secondary data analysis)
- Unger S, Cunningham S. Effect of oxygen supplementation on length of stay for infants hospitalized with acute viral bronchiolitis. Pediatrics. 2008;121(3):470-475. (Retrospective; 129 patients)
- Norwood A, Mansbach JM, Clark S, et al. Prospective multicenter study of bronchiolitis: predictors of an unscheduled visit after discharge from the emergency department. Acad Emerg Med. 2010;17(4):376-382. (Prospective cohort multicenter study; 722 patients aged <2 years) DOI: 10.1111/j.1553-2712.2010.00699.x
- Bakel LA, Hamid J, Ewusie J, et al. International variation in asthma and bronchiolitis guidelines. Pediatrics. 2017;140(5). (Review)
- American Medical Association. CPT® evaluation and management (E/M) office or other outpatient (99202-99215) and prolonged services (99354, 99355, 99356, 99417) code and guideline changes. 2021. Accessed December 10, 2022. (Summary of coding guidelines)